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  "_id": "6a102a82acfb0bcc41c920e3",
  "Package": "qpNCA",
  "Type": "Package",
  "Title": "Noncompartmental Pharmacokinetic Analysis by qPharmetra",
  "Version": "1.1.6",
  "Authors@R": "c(person(\"Jan\", \"Huisman\", role = c(\"aut\", \"cre\"),\nemail = \"jan.huisman@qpharmetra.com\"),\nperson(\"Koen\", \"Jolling\", role = \"ctb\"),\nperson(\"Krina\", \"Mehta\", role = \"ctb\"),\nperson(\"Tim\", \"Bergsma\", role = \"ctb\"))",
  "Author": "Jan Huisman [aut, cre], Koen Jolling [ctb], Krina Mehta [ctb],\nTim Bergsma [ctb]",
  "Maintainer": "Jan Huisman <jan.huisman@qpharmetra.com>",
  "Description": "Computes noncompartmental pharmacokinetic parameters for\ndrug concentration profiles.  For each profile, data\nimputations and adjustments are made as necessary and basic\nparameters are estimated. Supports single dose, multi-dose, and\nmulti-subject data.  Supports steady-state calculations and\nvarious routes of drug administration. See ?qpNCA and\nvignettes. Methodology follows Rowland and Tozer (2011,\nISBN:978-0-683-07404-8), Gabrielsson and Weiner (1997,\nISBN:978-91-9765-100-4), and Gibaldi and Perrier (1982,\nISBN:978-0824710422).",
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  "Packaged": {
    "Date": "2026-05-13 06:55:46 UTC",
    "User": "root"
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  "Repository": "https://huismanj.r-universe.dev",
  "Date/Publication": "2021-08-16 11:50:02 UTC",
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      "page": "calc.ctmax",
      "title": "Calculate Cmax and Tmax",
      "topics": [
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      ]
    },
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      "page": "calc.par",
      "title": "Calculate NCA Parameters",
      "topics": [
        "calc.par"
      ]
    },
    {
      "page": "calc.par.th",
      "title": "Calculate Lambda_z Parameters",
      "topics": [
        "calc.par.th"
      ]
    },
    {
      "page": "check.input",
      "title": "Check qpNCA function arguments for validity",
      "topics": [
        "check.input"
      ]
    },
    {
      "page": "correct.conc",
      "title": "Correct Missing Concentration",
      "topics": [
        "correct.conc"
      ]
    },
    {
      "page": "correct.loq",
      "title": "Impute Concentrations Below the Limit of Quantitation",
      "topics": [
        "correct.loq"
      ]
    },
    {
      "page": "correct.time",
      "title": "Correct Concentrations for Time Deviations",
      "topics": [
        "correct.time"
      ]
    },
    {
      "page": "est.thalf",
      "title": "Calculate Lambda_z and Elimination Half-life",
      "topics": [
        "est.thalf"
      ]
    },
    {
      "page": "filenamefun",
      "title": "Create File Name for Regression Plots",
      "topics": [
        "filenamefun"
      ]
    },
    {
      "page": "interpol",
      "title": "Interpolate Concentrations",
      "topics": [
        "interpol"
      ]
    },
    {
      "page": "lag_lead",
      "title": "Estimate Lagging and Leading Times and Concentrations",
      "topics": [
        "lag_lead"
      ]
    },
    {
      "page": "plot_reg",
      "title": "Plot Regression Curves",
      "topics": [
        "plot_reg"
      ]
    },
    {
      "page": "qpNCA",
      "title": "Perform Non-compartmental Analysis",
      "topics": [
        "qpNCA"
      ]
    },
    {
      "page": "tab.corr",
      "title": "Tabulate Corrections",
      "topics": [
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      ]
    },
    {
      "page": "titlefun",
      "title": "Create Title for Regression Plots",
      "topics": [
        "titlefun"
      ]
    },
    {
      "page": "trap",
      "title": "Calculate Area Under the Curve Using Trapezoids",
      "topics": [
        "trap"
      ]
    },
    {
      "page": "trapm",
      "title": "Calculate Area Under the Moment Curve Using Trapezoids",
      "topics": [
        "trapm"
      ]
    }
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      "filename": "User_Guide.html",
      "title": "qpNCA User Guide",
      "author": "Jan Huisman",
      "engine": "knitr::rmarkdown",
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      "modified": "2021-07-13 14:10:02",
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      "title": "full-nca-analysis.rmd",
      "author": "Jan Huisman",
      "engine": "knitr::knitr",
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        "Load libraries",
        "Define mutate_cond and locf functions",
        "Check out Theoph data and prepare data for NCA",
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        "Print results"
      ],
      "created": "2021-07-13 14:10:02",
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      "author": "Jan Huisman",
      "engine": "knitr::knitr",
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        "Define mutate_cond and locf functions",
        "Check out Theoph data and prepare data for NCA",
        "Impute LOQ values",
        "Estimation of terminal half-life",
        "Plot individual regression plots",
        "Calculate Cmax and Tmax",
        "Correct time deviations at critical time points",
        "Impute missing concentrations at critical time points",
        "Tabulate corrections",
        "Calculate PK parameters NOT based on lambda_z",
        "Calculate PK parameters based on lambda_z",
        "Combine All NCA parameters in one data frame"
      ],
      "created": "2021-07-13 14:10:02",
      "modified": "2021-07-13 14:10:02",
      "commits": 1
    },
    {
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      "title": "Parameter Guidelines",
      "author": "Koen Jolling, Jan Huisman",
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      "headings": [],
      "created": "2021-07-13 14:10:02",
      "modified": "2021-07-13 14:10:02",
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