Package: qpNCA 1.1.6

qpNCA: Noncompartmental Pharmacokinetic Analysis by qPharmetra

Computes noncompartmental pharmacokinetic parameters for drug concentration profiles. For each profile, data imputations and adjustments are made as necessary and basic parameters are estimated. Supports single dose, multi-dose, and multi-subject data. Supports steady-state calculations and various routes of drug administration. See ?qpNCA and vignettes. Methodology follows Rowland and Tozer (2011, ISBN:978-0-683-07404-8), Gabrielsson and Weiner (1997, ISBN:978-91-9765-100-4), and Gibaldi and Perrier (1982, ISBN:978-0824710422).

Authors:Jan Huisman [aut, cre], Koen Jolling [ctb], Krina Mehta [ctb], Tim Bergsma [ctb]

qpNCA_1.1.6.tar.gz
qpNCA_1.1.6.zip(r-4.7-any)qpNCA_1.1.6.zip(r-4.6-any)qpNCA_1.1.6.zip(r-4.5-any)
qpNCA_1.1.6.tgz(r-4.6-any)qpNCA_1.1.6.tgz(r-4.5-any)
qpNCA_1.1.6.tar.gz(r-4.7-any)qpNCA_1.1.6.tar.gz(r-4.6-any)
qpNCA_1.1.6.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION
card.svg |card.png
qpNCA/json (API)

# Install 'qpNCA' in R:
install.packages('qpNCA', repos = c('https://huismanj.r-universe.dev', 'https://cloud.r-project.org'))

On CRAN:

Conda:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

3.88 score 38 scripts 286 downloads 10 exports 34 dependencies

Last updated from:03f47c2925. Checks:7 WARNING, 2 OK. Indexed: yes.

TargetResultTimeFilesSyslog
linux-develWARNING126
source / vignettesOK185
linux-releaseWARNING139
macos-releaseWARNING217
macos-oldrelWARNING191
windows-develWARNING79
windows-releaseWARNING106
windows-oldrelWARNING107
wasm-releaseOK105

Exports:calc.ctmaxcalc.parcalc.par.thcorrect.conccorrect.loqcorrect.timeest.thalfplot_regqpNCAtab.corr

Dependencies:clicpp11dplyrevaluatefarvergenericsggplot2gluegtablehighrisobandknitrlabelinglifecyclemagrittrpillarpkgconfigpurrrR6RColorBrewerrlangS7scalesstringistringrtibbletidyrtidyselectutf8vctrsviridisLitewithrxfunyaml

qpNCA User Guide
Rendered fromUser_Guide.rmdusingknitr::rmarkdown

Last update: 2021-07-13
Started: 2021-07-13

full-nca-analysis.rmd
Load libraries | Define mutate_cond and locf functions | Check out Theoph data and prepare data for NCA | Run full NCA analysis | Print results
Rendered fromExample-full-nca-analysis.rmdusingknitr::knitr

Last update: 2021-07-13
Started: 2021-07-13

stepwise-nca-analysis.rmd
Load libraries | Define mutate_cond and locf functions | Check out Theoph data and prepare data for NCA | Impute LOQ values | Estimation of terminal half-life | Plot individual regression plots | Calculate Cmax and Tmax | Correct time deviations at critical time points | Impute missing concentrations at critical time points | Tabulate corrections | Calculate PK parameters NOT based on lambda_z | Calculate PK parameters based on lambda_z | Combine All NCA parameters in one data frame
Rendered fromExample-stepwise-nca-analysis.rmdusingknitr::knitr

Last update: 2021-07-13
Started: 2021-07-13

Parameter Guidelines
Rendered fromParameter_Guidelines.rmdusingknitr::rmarkdown

Last update: 2021-07-13
Started: 2021-07-13